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H2Biologics

Shrewsbury, Massachusetts, United Statesbiopharmguy.com ↗

Ownership: Private
Development stage: Other

Overview

H2Biologics is developing a novel antibody-drug conjugate that links a human single domain antibody targeting mesothelin to human granzyme B, a serine protease. Preclinical studies have demonstrated potent anti-tumor activity in cell culture and xenograft models with lower systemic toxicity compared to conventional toxins. The lead program is in preclinical development for multiple solid tumors expressing mesothelin, including pancreatic and ovarian cancers.

Therapeutic areas: Oncology
Modalities: Antibody-drug conjugateAntibodyProtein (Granzyme B-based immunoconjugate)
Industry: Biotech

Partnerships

Research Development Foundation/Clayton Foundation for Research (licensing and sponsored research agreement)University of Texas MD Anderson Cancer Center (originator of technology; research collaboration)

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