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Yirui Pharma has successfully completed a U.S. Phase I clinical trial for its lead candidate, YR001, a topical Kv1.3 inhibitor for autoimmune skin diseases such as atopic dermatitis and psoriasis, demonstrating favorable safety and tolerability. The oral formulation of this compound targets inflammatory bowel disease and alopecia, with plans for NDA submissions between 2026–2028. Additional pipeline assets are in preclinical or IND stages targeting diabetic complications, retinal disease, pruritus, and erectile dysfunction.
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