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Hemerion Therapeutics

Ownership: Private
Employees: ~50
Development stage: Phase 2

Overview

Hemerion’s lead program combines the photosensitizer Pentalafen® with the Heliance® illumination device to destroy residual glioblastoma cells after surgical resection. The INDYGO feasibility study showed high tolerance and encouraging efficacy, with half of patients achieving progression-free survival beyond 17 months. The ongoing HTX‑GBM‑01 Phase 1/2 trial follows FDA IND clearance and Fast Track designation. Hemerion received Orphan Drug Designation in 2021, and Fast Track status by the FDA in early 2025. The approach could redefine standard of care by potentially removing the need for radiotherapy post-surgery.

Therapeutic areas: Oncology
Modalities: Drug-device combination therapyphotosensitizing small molecule (Pentalafen®)photonic illumination platform (Heliance®)
Industry: Biotech

Drug pipeline

1 asset

pentalafen + heliance

Phase 2

Indications: Glioblastoma

Partnerships

University of Lille / Lille University Hospital / Inserm [co-development partners for technology development and early trials]University of Pittsburgh Medical Center [clinical trial partner for US-based phase I/II study].

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