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Histone Therapeutics

Seattle, Washington, United Stateshistonetx.com ↗

Ownership: Private
Development stage: Preclinical

Overview

Histone Therapeutics develops precision epigenetic therapies to restore or amplify gene expression without altering DNA. Their “ON” platform uses transient mRNA delivery and engineered protein effectors to activate silenced genes. The company’s main focus includes developing novel treatments for cancer—particularly blood cancers—by remodeling natural killer cells and targeting misregulated genes implicated in disease. As of now, their programs appear to be preclinical with no reported human trial results.

Therapeutic areas: OncologyRare DiseasesNeurology
Modalities: Epigenetic reprogramming (precision epigenetic reprogramming)Transient mRNA delivery via non-viral vectorsEngineered protein effectors for gene activation/repressionNatural killer (NK) cell therapies (for blood cancer)
Industry: Biotech

Partnerships

Open to partnerships with collaborators specializing in disease areas or genetic delivery technologies; no major pharma partnerships disclosed yet

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