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ICE (Industria Chimica Emiliana) is a global leader in the production of bile acid derivatives, most notably Ursodeoxycholic Acid (UDCA), which is used to treat various liver diseases and gallstones. Founded in 1949 and headquartered in Reggio Emilia, Italy, the company maintains a unique, vertically integrated supply chain for bovine bile collection across Europe, the Americas, and Asia. ICE operates several GMP-certified manufacturing facilities and provides high-purity active pharmaceutical ingredients (APIs) to major pharmaceutical companies worldwide. In 2019, the private equity firm Advent International acquired a majority stake in the company to support its international expansion and product diversification. The company's expertise lies in complex chemical synthesis and the large-scale extraction of natural substances for therapeutic use.
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