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GCC19CART has shown robust clinical activity for relapsed/refractory metastatic colorectal cancer. In a Chinese dose-escalation study at dose level 2 (2 x 10^6 CAR-T/kg), ORR was 50% with median overall survival exceeding 26 months. In the U.S. Phase I trial, at dose level 1 (1 x 10^6 CAR-T/kg), ORR was also 50% with mOS of 17 months; at dose level 2 (12 x 10^6 CAR-T/kg), ORR reached 80%, mOS not yet reached
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