Integrated Centre of Nephrology

Centro Integrado de Nefrologia (CINE), widely recognized in international medical literature as the Integrated Centre of Nephrology, is a specialized kidney care and dialysis facility based in Guarulhos, Brazil. The center provides high-efficiency hemodialysis and comprehensive nephrology services for patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD). It is particularly noted for its contributions to clinical research, specifically the CLOCK trial, which evaluated the efficacy of various antimicrobial lock solutions in preventing catheter-related complications. In 2019, the center was acquired by DaVita, a global leader in kidney care, and now operates as part of DaVita's extensive network in Brazil. The facility continues to serve as a reference center for advanced renal care and clinical excellence in the São Paulo region.