International Spine Study Group

The International Spine Study Group (ISSG) is a non-profit research foundation dedicated to improving the care of patients with adult spinal deformity. The group consists of leading spine surgeons and researchers from across the United States and internationally who collaborate on large-scale, multicenter prospective studies. ISSG maintains one of the world's largest databases of adult spinal deformity patients, enabling high-impact clinical research on surgical outcomes, complications, and cost-effectiveness. Their work significantly influences clinical guidelines and the development of surgical techniques and spinal instrumentation. The foundation is supported by industry grants and is recognized for its contributions to predictive modeling in complex spine surgery.