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IO Biotech's lead program, a combination vaccine targeting IDO1 and PD-L1 antigens (IO102-IO103), is in Phase III trials for advanced melanoma. Interim analyses have shown promising response rates and safety profiles when combined with pembrolizumab. The primary endpoint of progression-free survival is expected to be reached in the first half of 2025. Earlier studies showed a complete response rate of up to ~45% and overall response rates near ~79% when combined with checkpoint inhibitors.[6][10]
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