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Isofol Medical

Ownership: Private
Development stage: Phase 3

Overview

Isofol’s lead candidate arfolitixorin is a novel folate-based compound designed to enhance the efficacy of 5-FU-based chemotherapy. A global Phase III trial in metastatic colorectal cancer did not meet its primary endpoint, but preclinical and clinical data suggest dose-dependent activity. The company is now conducting a new Phase Ib/II study with an optimized dosing regimen to further evaluate efficacy and safety in first-line metastatic colorectal cancer patients.

Therapeutic areas: Oncology
Modalities: Small molecules
Industry: Biotech

Drug pipeline

1 asset

arfolitixorin

Partnerships

Solasia Pharma K.K. – rights to arfolitixorin/SP‑05 in Japan, resumed development as of March 2024.

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