Juvenile Bipolar Research Foundation

The Juvenile Bipolar Research Foundation (JBRF) is a non-profit organization dedicated to advancing the understanding and treatment of early-onset bipolar disorder. The foundation is recognized for its pioneering research into the 'Fear of Harm' phenotype, a distinct clinical profile characterized by sleep disturbances, thermoregulatory issues, and intense behavioral symptoms. JBRF supports and conducts clinical trials for innovative therapies, including the use of intranasal ketamine and light therapy, to address the specific biological drivers of the condition. By integrating genetic studies with clinical observation, the foundation aims to improve diagnostic precision and provide more effective, targeted interventions for children and their families. Their work also includes the development of standardized diagnostic tools used by clinicians worldwide.