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Keros Therapeutics is advancing multiple clinical-stage assets targeting dysfunctional signaling of the transforming growth factor-beta family. Its lead program, elritercept, is in Phase III trials for transfusion-dependent anemia in MDS. Another candidate, cibotercept, was discontinued after safety concerns in PAH. Early-stage asset KER‑065 has shown promising tolerability and activity in neuromuscular disease models; a Phase II trial is planned for DMD pending regulatory feedback. The company recently entered into a major partnership with Takeda to develop elritercept globally except China regions.
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