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Kotobuki Pharmaceutical has a history of developing both original and generic pharmaceuticals. Notably, it co-developed the SGLT2 inhibitor ipragliflozin ("Suglat") for type II diabetes with Astellas Pharma. The company also contributed to the development of gilteritinib ("Xospata"), an FLT3 inhibitor for relapsed/refractory acute myeloid leukemia—now FDA-approved through Astellas. Other marketed drugs include treatments for gastrointestinal disorders, pain management, neurological diseases, and metabolic conditions.
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