Letters

Letters (stylized as Letters.bio) is a biotechnology company focused on expanding the genetic code through the engineering of transfer RNA (tRNA). Founded by renowned CRISPR pioneers Omar Abudayyeh and Jonathan Gootenberg, the company leverages programmable biology to develop novel therapeutic modalities that can address a wide range of genetic disorders. By treating the genetic code as a programmable medium, Letters aims to create "molecular letters" that can override mutations or introduce new functionalities into protein synthesis. The company operates at the intersection of synthetic biology and RNA therapeutics, building on the founders' extensive work in novel CRISPR enzymes and cellular engineering.