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Libra Therapeutics has developed a pipeline of novel small molecule therapeutics targeting key mechanisms underlying neurodegenerative diseases. Their lead program targets TRPML1 to enhance autophagy and lysosomal function. As of mid/late 2024, all programs remain preclinical with the first-in-human trial planned for their TRPML1-targeting candidate in early/mid–2025. No clinical results have been reported yet.
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