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Lief Therapeutics markets an FDA class II electrocardiogram wearable patch and software platform that deliver heart rate variability (HRV) biofeedback for mental health. The device (including prescription-only Lief Rx) is indicated for HRV-based relaxation training and muscle re-education that, as part of a healthy lifestyle, may help reduce risk of anxiety and depression. It is in commercial use with consumers and in clinical and payer pilots for anxiety, depression, PTSD, and addiction, including at Harvard, the U.S. Veterans Administration, CVS Health, and Optum.[2][4]
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