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Lionheart Ventures is an active venture capital firm based in San Francisco that invests globally at the seed stage. The firm focuses on transformative technologies with particular emphasis on artificial intelligence and frontier mental health solutions—including psychedelic medicine and neuromodulation. Their mission centers around mitigating civilizational risks and supporting technologies that enhance human resilience and well-being. Notable investments include Anthropic (AI), Calm (mental health/wellness app), Reconnect Labs (clinical-stage pharma for mental health), Psylo, Journey Clinical, TRIPP, Sanmai, among others. The team includes experienced entrepreneurs and domain experts with backgrounds in technology startups and healthcare.
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