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Lorantis was a Cambridge-based biotechnology company specializing in the development of immunotherapeutics that modulate the Notch signaling pathway. The company's technology focused on inducing antigen-specific immune tolerance or activation to treat autoimmune diseases, allergies, and cancer. Its lead programs included therapies for graft-versus-host disease and various oncology indications. In 2005, Lorantis was acquired by Celldex Therapeutics to bolster Celldex's immunotherapy pipeline and platform. The acquisition integrated Lorantis's expertise in Notch signaling with Celldex's focus on targeted cancer therapies.
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