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Lowell Therapeutics' lead asset, Niyad, is a lyophilized formulation of nafamostat, a synthetic serine protease inhibitor acting as a regional anticoagulant for dialysis circuits. It received FDA Breakthrough Device Designation and is not yet commercialized in the U.S., though the active drug has approval in Japan and South Korea for related indications. No FDA-approved products currently exist for this indication in the U.S.[3][5][9]
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