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Lydex Pharmaceuticals developed small molecule HDAC inhibitors for liver ischemia/reperfusion injury and leukemia. Their lead programs were in preclinical development as of early 2025. LP340 showed protective effects against liver injury and fibrosis in animal models, likely via epigenetic upregulation of antioxidant proteins and modulation of inflammatory pathways. No clinical results are available; the company is now defunct.[1][2][3][7]
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