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MacuCLEAR developed a novel topical small molecule therapy (MC‑1101) to treat and slow progression of dry age-related macular degeneration by improving ocular blood flow. The active ingredient in MC‑1101 had prior FDA approval as an oral antihypertensive. Clinical results included a successful Phase Ib proof-of-concept study and initiation of Phase II/III trials. The company also pursued additional compounds for diabetic retinopathy and other retinal vascular diseases. In May 2010, MacuCLEAR was acquired by Healthcare of Today.
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