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Makana Holdings
Miami, Florida, United States
- Ownership
- Private
- Development stage
- Other
01
Overview
Makana Therapeutics has developed Triple Knockout (TKO) and TKO plus SLA DR knockout pigs that have produced the first 1‑year preclinical xeno-kidney survivor and the longest, most consistent preclinical survival data in the xenotransplantation field; the company is in discussions with the U.S. FDA regarding initiation of the first human clinical trial in kidney xenotransplantation, but no human trials are yet reported as started[1][5][6].
- Therapeutic areas
- EndocrinologyCardiovascularNephrologyRare Diseases
- Modalities
- Cell therapyOrgan transplantation technologyBiologic
- Industry
- Biotech
02
Partnerships
Tonix Pharmaceuticals (collaborative research agreement to combine Makana’s genetically engineered pig organs with TNX-1500, an anti‑CD40L monoclonal antibody, for preclinical and future clinical xenotransplantation studies)[1][4][5].
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