Company intelligence / Profile preview
Marengo Therapeutics
Cambridge, MA, United Statesmarengotx.com ↗
- Ownership
- Private
- Employees
- ~42
- Development stage
- Other
01
Overview
Marengo Therapeutics has reported encouraging single-agent anti-tumor activity from its lead asset invikafusp alfa (STAR0602), particularly in PD1-resistant "cold" tumors. The FDA granted Fast Track designation to invikafusp alfa for treatment of tumor mutational burden-high colorectal cancer based on first-in-human Phase I results. The company’s approach leverages biomarker-driven trial design and focuses on durable immune responses by activating specific subsets of the human T-cell repertoire. Combination trials with Gilead's Trodelvy are ongoing/planned.
- Therapeutic areas
- OncologyImmunologyInfectious Diseases
- Modalities
- Antibody fusion proteins (e.g., T-cell activators and engagers)Bispecific antibodiesTrispecific antibodies
- Industry
- Biotech
02
Drug pipeline
12 assets11 more assets in the full pipeline.
03
Partnerships
Gilead Sciences – collaboration to combine invikafusp alfa with Trodelvy in advanced solid tumor trials[6].University of Pennsylvania Institute for Immunology and Immune Health / Dr. E John Wherry – multi-year research collaboration focused on mechanism-of-action studies and expansion into autoimmunity using the MSTAR platform[10].King’s College London – immuno-oncology research collaboration involving STAR0602 development/preclinicals [9].
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