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Marvel Biosciences is developing MB-204, a novel fluorinated derivative of the anti-Parkinson’s drug istradefylline targeting the adenosine A2a receptor. Preclinical studies have shown efficacy in models of Alzheimer’s disease, depression, anxiety, autism spectrum disorder, Rett syndrome and Fragile X syndrome. The company has completed cGMP synthesis and toxicology studies and is preparing for Phase 1 clinical trials.
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