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MDRNA was an early innovator in the field of RNA-based therapeutics. The company developed proprietary technologies for delivering small interfering RNAs (siRNAs) and other oligonucleotides. It advanced several preclinical programs targeting cancer and metabolic diseases but did not achieve late-stage clinical success or commercialization before rebranding as Marina Biotech in 2010. Afterward, it underwent further business transitions.
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