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MediLink Therapeutics

Suzhou, Jiangsu, China
Ownership
Private
Employees
~34
Development stage
Phase 3
01

Overview

MediLink has advanced several proprietary ADC candidates into clinical development. Notably, YL201 has received orphan drug designation from the FDA and launched a Phase I/II study. HBM9033/YL215, targeting mesothelin for solid tumors, was developed with Nona Biosciences using the TMALIN® platform; it demonstrated superior potency/safety preclinically and received FDA IND clearance in August 2023. A BioNTech-partnered asset faced an FDA hold due to safety concerns at higher doses during a US trial. The company continues to expand its pipeline through internal R&D and major outlicensing deals.

Therapeutic areas
OtherOncology
Modalities
Antibody-drug conjugates (ADCs)Monoclonal antibodies (mAbs, via partnerships)
Industry
Biotech
02

Drug pipeline

11 assets

YL202

3

10 more assets in the full pipeline.

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03

Partnerships

BioNTech – multi-target TMALIN® ADC license agreement ($1B+ deal value reported); partnered asset currently on partial clinical hold by FDA due to safety concerns at high dose levels during US trial enrollmentPfizer – sublicensee of HBM9033/YL215 via Nona Biosciences partnership; MediLink receives sub-license payments from this collaborationRoche – collaboration on YL211 programZai Lab – collaboration on YL212Harbour BioMed/Nona Biosciences – co-development of HBM9033/YL215 using Harbour Mice® antibody discovery platform

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