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Mediterranea Theranostic’s first anti-Trop-2 antibody-drug conjugate entered clinical trials in December 2023, in cancer patients at major cancer centers (Harvard’s Dana-Farber, MD Anderson), with clinical results for the LCB84 program expected in 2025. Preclinical validation showed strong anti-tumor efficacy, and a major license/partnership with LegoChem Biosciences accelerated development.
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