Megabios

Megabios was a pioneering biotechnology company focused on the development of non-viral gene therapy systems. Founded in 1992, the company specialized in using plasmid DNA and proprietary cationic lipid-based delivery technologies to treat genetic and acquired diseases. Its lead programs included treatments for cystic fibrosis and various cancers, developed in collaboration with major pharmaceutical partners like Glaxo Wellcome and Pfizer. The company's approach was designed to overcome the safety and manufacturing limitations associated with viral vectors. In 1999, Megabios merged with GeneMedicine to form Valentis, marking a significant consolidation in the early gene therapy industry.