Mesima Research Institute

Mesima Research Institute is the specialized research and development division of Hankook Shinyak, a South Korean pharmaceutical company focused on medicinal mushroom-derived therapeutics. The institute is primarily dedicated to the development and clinical study of Mesima (PL2/PL5), a highly purified polysaccharide extract from the Phellinus linteus mushroom. Mesima is utilized as an immunomodulatory adjuvant in oncology, specifically approved in South Korea for the treatment of gastric cancer and hepatocellular carcinoma. The institute's research emphasizes the activation of natural killer cells, macrophages, and T-lymphocytes to enhance the body's anti-tumor immune response. As a pioneer in fungal-based medicine, the institute continues to explore the therapeutic potential of mushroom metabolites for various immune-related conditions.