Company intelligence / Profile preview

MethylGene Inc.

Montreal, Quebec, Canadamethylgene.com ↗

Ownership: Private
Development stage: Other

Overview

MethylGene developed small molecule therapeutics targeting cancer and infectious diseases. Its lead candidates included MGCD265 (multi-targeted kinase inhibitor for solid tumors), MGCD290 (fungal Hos2 inhibitor for candidiasis), mocetinostat/MGCD0103 (HDAC inhibitor for cancer), and EVP‑0334 for neurodegenerative disease. Several programs reached Phase I or II trials but were discontinued or licensed out as the company ceased independent operations.[1][5]

Therapeutic areas: OncologyInfectious Diseases
Modalities: Small molecules[5][6]Enzyme inhibitorsKinase inhibitorsHDAC inhibitors
Industry: Biotech

Partnerships

Otsuka Pharmaceutical Co. Ltd. – collaboration on ocular disease applications using proprietary kinase chemistry [5].Taiho Pharmaceutical Co. Ltd. – licensee of mocetinostat in certain Asian countries [5].EnVivo Pharmaceuticals – sponsored development of EVP‑0334 for neurodegeneration [5].

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