Metronomics Global Health Initiative

The Metronomics Global Health Initiative (MGHI) is a non-profit organization focused on expanding access to affordable cancer treatments in low- and middle-income countries. The initiative promotes the use of metronomic chemotherapy, which involves the continuous administration of low-dose cytotoxic drugs to achieve anti-angiogenic and immunomodulatory effects with minimal toxicity. By repurposing off-patent medications such as cyclophosphamide and methotrexate, MGHI develops sustainable protocols for pediatric and adult oncology. The organization coordinates international clinical trials, provides clinical training, and collaborates with global health partners to integrate metronomics into standard care. Their work specifically targets resource-limited settings where conventional high-dose chemotherapy and its associated supportive care are often unavailable or unaffordable. MGHI's mission is to bridge the gap in global cancer care through "frugal innovation" and evidence-based clinical research.