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Milestone received FDA approval for Cardamyst (etripamil) in December 2024 for acute symptomatic PSVT episodes. The Phase III RAPID study showed 64% of patients converted to sinus rhythm within 30 minutes versus 31% on placebo, with median onset of 17 minutes versus 54 minutes for placebo. Cardamyst is the first novel approved treatment for PSVT in more than 30 years.
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