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Modifi Biosciences
New Haven, Connecticut, United Statesmodifibio.com ↗
- Ownership
- Private
- Development stage
- Preclinical
01
Overview
The company developed a new class of orally deliverable small molecules that selectively kill cancer cells by directly modifying their DNA, bypassing traditional protein-targeting approaches. Their lead compounds demonstrated robust anti-tumor activity in preclinical models including patient-derived xenografts. Research published in Science validated their approach targeting MGMT-deficient tumors and overcoming resistance mechanisms[1][2][5].
- Therapeutic areas
- Oncology
- Modalities
- Small molecules designed for oral delivery that directly modify cancer cell DNA
- Industry
- Biotech
02
Partnerships
Yale University spinout originInvestors included HighCape Capital, Advantage Capital, Connecticut Innovations, BrightEdge Entrepreneurs Program/American Cancer Society impact arm, National Brain Tumor Society's Brain Tumor Investment Fund, Pathway Bioventures, Sontag Innovation Fund among others before acquisition[2][9].Post-acquisition partnership integrated into Merck’s oncology research pipeline.
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