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Mytogen developed a proprietary cell therapy using autologous skeletal muscle-derived myoblasts to treat heart failure and myocardial injury. The company completed Phase I clinical trials demonstrating safety and some evidence of improved cardiac function, with plans to initiate multi-center Phase II studies before being acquired by Advanced Cell Technology in 2007. Over forty patients were treated in early trials, with four independent studies supporting safety. The FDA allowed progression to Phase II based on end-of-Phase I data.
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