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Neoclease

Massachusetts, United Statesneoclease.ai ↗

Ownership: Private
Development stage: Preclinical

Overview

Neoclease has developed a proprietary platform that uses generative AI to design highly specific synthetic nucleases for gene editing. Their technology aims to minimize off-target effects and enable precise correction of disease-causing genes. To date, they have generated tens of thousands of novel nuclease sequences computationally and advanced about 7,000 into further validation. Some miniaturized editors show comparable efficacy to CRISPR-Cas9 but with significantly reduced off-target activity. Most results are currently from computational or limited in vitro testing; animal model studies are expected soon.[1][3][5][6]

Therapeutic areas: Infectious DiseasesRare DiseasesNeurologyWomen's Health
Modalities: Custom nucleases (gene-editing enzymes)Synthetic biology-based gene editorsAI-designed protein therapeutics[1][3][6]
Industry: Biotech

Drug pipeline

2 assets

NCX-L2

Preclinical

1 more asset in the full pipeline.

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Partnerships

Collaborations with industry leaders/pharma companies on evaluation of nuclease libraries[1][3][5]Academic collaborations through CTO Prof. Jin Liu's university lab[4]

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