Company intelligence / Profile preview
Neoclease
Massachusetts, United Statesneoclease.ai ↗
- Ownership
- Private
- Development stage
- Preclinical
01
Overview
Neoclease has developed a proprietary platform that uses generative AI to design highly specific synthetic nucleases for gene editing. Their technology aims to minimize off-target effects and enable precise correction of disease-causing genes. To date, they have generated tens of thousands of novel nuclease sequences computationally and advanced about 7,000 into further validation. Some miniaturized editors show comparable efficacy to CRISPR-Cas9 but with significantly reduced off-target activity. Most results are currently from computational or limited in vitro testing; animal model studies are expected soon.[1][3][5][6]
- Therapeutic areas
- Infectious DiseasesRare DiseasesNeurologyWomen's Health
- Modalities
- Custom nucleases (gene-editing enzymes)Synthetic biology-based gene editorsAI-designed protein therapeutics[1][3][6]
- Industry
- Biotech
02
Drug pipeline
2 assets1 more asset in the full pipeline.
03
Partnerships
Collaborations with industry leaders/pharma companies on evaluation of nuclease libraries[1][3][5]Academic collaborations through CTO Prof. Jin Liu's university lab[4]
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