Company intelligence / Profile preview
NeoPhore
London, England, United Kingdomneophore.com ↗
- Ownership
- Private
- Development stage
- Other
01
Overview
NeoPhore has demonstrated in preclinical models that its small molecule inhibitors targeting the MMR pathway can induce neoantigen expression, increase tumor mutational burden, and sensitize tumors to immune checkpoint blockade. The lead compound NP1867 functionally inhibits MMR in cells and elicits mutational signatures consistent with those seen in MMR-deficient patient samples. No clinical trial results have been reported yet; IND-enabling studies are ongoing or imminent.
- Therapeutic areas
- Oncology
- Modalities
- Small molecules
- Industry
- Biotech
02
Drug pipeline
3 assets2 more assets in the full pipeline.
03
Partnerships
Memorial Sloan Kettering Cancer Center (MSK) – research collaboration on proprietary DNA mismatch repair inhibitor compoundsSt George’s, University of London – research partnership on cancer immunotherapiesInstitute of Cancer Research, London – strategic collaboration for new cancer drugs targeting the MMR pathway
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