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Obicetrapib, a novel oral CETP inhibitor, has demonstrated significant LDL-C lowering effects in high-risk cardiovascular patients on top of statins. In the BROOKLYN Phase 3 trial, it reduced LDL cholesterol by up to ~41% at one year versus placebo and showed a safety profile comparable to placebo. Additional late-stage trials are ongoing or recently completed, with topline data reported for several studies and regulatory filings anticipated[1][2][4].
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