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Nynex Therapeutics is developing first-in-class, orally bioavailable small molecule inhibitors of deubiquitinases. These enzymes are implicated in the stabilization of oncogenic proteins and transcription factors that drive tumorigenesis. The company’s lead program is a pre-investigational new drug (pre-IND) candidate shown to be effective in preclinical models of cancer[2]. No clinical results have been reported yet.
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