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Ocean Biomedical is advancing a pipeline of next-generation immunotherapies and vaccines. Its lead oncology program uses bispecific antibodies targeting PD-(L)1, VEGF, CHI3L1, and CTLA4 to overcome resistance in EGFR-mutant NSCLC and other cancers. Preclinical data show strong tumor suppression. In infectious diseases, its NIH-funded malaria vaccine program targets GARP using mRNA/lipid nanoparticle delivery; non-human primate studies are ongoing with expedited FDA guidance potentially enabling first-in-human trials by late 2025.
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