Company intelligence / Profile preview

OncoC4

Rockville, Maryland, USAoncoc4.com ↗
Ownership
Private
Development stage
Phase 3
01

Overview

OncoC4’s lead candidate ONC‑392/gotistobart has advanced to late-stage clinical trials for solid tumors. The company has a strategic partnership with BioNTech for co-development and commercialization of ONC‑392. Early data suggest the approach may enhance anti-tumor activity while reducing autoimmune side effects compared to earlier CTLA‑4 inhibitors. Additional programs are advancing through preclinical and early clinical development targeting novel pathways such as PD‑1/VEGF bispecifics and Siglec agonists.

Therapeutic areas
OncologyNeurology
Modalities
monoclonal antibodies (mAbs)bispecific antibodies (BsAbs)antibody-drug conjugates (ADCs)CAR T-cell therapies
Industry
Biotech
02

Drug pipeline

13 assets

covid-19 antibody nasal spray

4

12 more assets in the full pipeline.

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03

Partnerships

BioNTech – exclusive worldwide license/co-development agreement for ONC–392/BNT316 ($200M upfront plus milestones & royalties)

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