Company intelligence / Profile preview

Opthea Limited

Melbourne, Victoria, Australiaopthea.com ↗
Ownership
Public · OPT
Development stage
Phase 3
01

Overview

Opthea Limited is advancing sozinibercept (formerly OPT‑302), a novel biologic targeting VEGF-C and VEGF-D, in two pivotal Phase 3 trials for wet AMD. In Phase 2b studies with ranibizumab, sozinibercept demonstrated superior visual outcomes compared to standard-of-care alone. The ongoing COAST and ShORe Phase 3 trials are fully enrolled with topline results expected in Q2 and mid‑2025 respectively. Sozinibercept could become the first new therapy in two decades to deliver improved vision outcomes for wet AMD patients when used alongside anti–VEGF-A therapies.

Therapeutic areas
Ophthalmology
Modalities
Biologics (VEGF-C/D ‘trap’ inhibitor)
Industry
Biotech
02

Drug pipeline

2 assets

sozinibercept

2

1 more asset in the full pipeline.

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