Orfuel

Orfuel is a San Diego-based biotechnology company specializing in the development of oral formulations for peptide-based drugs. The company's primary mission is to convert injectable biologics into convenient oral tablets, thereby improving patient compliance and expanding access to essential treatments. Orfuel's proprietary technology platform focuses on enhancing the oral bioavailability of peptides, with an initial emphasis on metabolic diseases such as obesity and type 2 diabetes. Led by the founder of Crinetics Pharmaceuticals, the company leverages deep expertise in endocrinology and drug delivery to advance its pipeline of next-generation metabolic therapies.