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OrganOx

Oxford/Oxford Science Park/Oxfordshire area*, England, United Kingdomorganox.com ↗

Ownership: Private
Development stage: Commercial

Overview

The metra® device has demonstrated significant improvements in transplant outcomes. Clinical trials showed a reduction in early allograft dysfunction from ~30% to ~10% compared to static cold storage. A European randomized trial found a halving of discarded livers and a >20% increase in transplanted livers using the metra®. Over 5,000 transplants have been supported globally with regulatory approvals in the US, Europe, Canada, and Australia. FDA clearance was recently obtained for first-in-human studies combining metra® with genetically engineered porcine livers.

Therapeutic areas: GastroenterologyNephrologyOther
Modalities: Device (Normothermic machine perfusion system)Non-pharmacological therapy (Organ preservation and assessment)
Industry: Therapeutic Medical Devices

Drug pipeline

1 asset

metra

Commercial

Indications: Liver transplantation

Partnerships

Ochre Bio – partnership to evaluate RNA therapeutics on ex vivo donor livers using the metra deviceProCure On-Demand – partnership to expand access for US liver transplants via combined logistics/services offeringeGenesis – co-development agreement on advanced extracorporeal therapies/xenotransplants using genetically modified pig organs + FDA IND clearance as of April-May '25.

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