Original Discovery

Original Discovery was a specialized drug discovery company based in Oxford, UK, that focused on leveraging human genetics and large-scale data science to identify and validate novel therapeutic targets. Founded by prominent industry figures, including Dr. Jonathan Knowles (former Head of R&D at Roche), the company aimed to bridge the gap between genomic insights and clinical drug development. Its approach involved analyzing complex genetic datasets to uncover the underlying biological drivers of disease, particularly in areas with high unmet medical needs. Although the company operated primarily in a stealth or semi-stealth mode, it was recognized for its high-caliber leadership and its focus on data-driven target prioritization. Original Discovery Limited was officially dissolved in early 2021.