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Orn Health

Watertown, Massachusetts, United States

Ownership: Private
Development stage: Other

Overview

Orna Therapeutics is a preclinical-stage biotechnology company developing engineered circular RNA (oRNA) therapeutics delivered by proprietary lipid nanoparticles for in vivo CAR and gene-editing–like applications in oncology, autoimmune, infectious, and genetic diseases; lead programs (e.g., ORN-252, ORN-101) have shown robust B cell and plasma cell depletion and tumor suppression in animal and non-human primate models, with first clinical entry planned around 2026.[1][2][4][6][8]

Therapeutic areas: OncologyInfectious DiseasesImmunologyHematology
Modalities: RNA therapymRNA-based drugsLipid nanoparticle delivery therapy
Industry: Biotech

Partnerships

Merck (collaboration to discover, develop, and commercialize multiple oRNA-based vaccines and therapeutics in infectious disease and oncology)[3][4]ReNAgade Therapeutics (joint venture for proprietary lipid nanoparticle delivery technologies)[3]

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