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OrsoBio

Palo Alto, California, United Statesorsobio.com ↗

Ownership: Private
Development stage: Preclinical

Overview

OrsoBio has completed or is conducting multiple early-stage clinical trials. Its lead programs include a liver-targeted mitochondrial protonophore in Phase 1b for obesity, an ACC2 inhibitor in Phase 2a for insulin resistance/diabetes, and an LXR inverse agonist in Phase 2a for severe hypertriglyceridemia/NASH. Preclinical work is ongoing on a controlled-release protonophore and an ACMSD inhibitor for metabolic/inflammatory disorders. No pivotal efficacy data have been published yet.

Therapeutic areas: GastroenterologyEndocrinologyMetabolic Disorders
Modalities: Small moleculeProtonophore (a type of small molecule)Inhibitor (small molecule)
Industry: Biotech

Drug pipeline

7 assets

TLC-2716

6 more assets in the full pipeline.

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Partnerships

Eli Lilly and Company (participated as investor)academic collaborations with Yale University (Gerald Shulman)EPFL (Johan Auwerx)Cincinnati Children’s Hospital Medical Center (Takanori Takebe)

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