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OtiTopic developed Asprihale (OTI-0726), an inhalable dry powder acetylsalicylic acid achieving peak plasma concentration and platelet aggregation inhibition in 2 minutes vs. 20 minutes for oral aspirin; planned NDA via 505(b)(2) pathway in 2022, but no approval reported as of 2025.[1][2][3][4][5]
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