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Oxy5 OncoMedical AG is a German biopharmaceutical company focused on developing innovative cancer treatments by targeting tumor metabolism. The company's research centers on the inhibition of transketolase-like 1 (TKTL1), an enzyme crucial for the metabolic reprogramming of cancer cells, also known as the Warburg effect. Their lead candidate, benfo-oxythiamine (B-OT), is a small molecule prodrug that releases oxythiamine to inhibit transketolase activity, thereby sensitizing cancer cells to chemotherapy, radiotherapy, and immunotherapy. Oxy5 aims to address treatment resistance and improve outcomes for patients with therapy-resistant tumors.
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