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Palisade Bio is a clinical-stage biopharmaceutical company focused on developing oral PDE4 inhibitor prodrugs for the treatment of autoimmune, inflammatory, and fibrotic diseases. The company's lead candidate, PALI-2108, is a locally-bioactivated PDE4 inhibitor designed to target the colon and ileum, providing potent anti-inflammatory effects while minimizing systemic exposure and associated side effects. Palisade Bio aims to transform the treatment landscape for inflammatory bowel diseases (IBD) through its precision pharmacology platform and targeted delivery technology. The company is currently advancing its lead program into Phase 2 clinical trials for Ulcerative Colitis.
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