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PENAO’s proprietary small molecule (ANT inhibitor) demonstrated safety and encouraging efficacy in a 26-patient Phase 1 clinical trial for advanced solid tumors. It showed dramatic improvements in cellular uptake and anti-tumor activity over GSAO, the earlier gold standard. Larger Phase 1/2 trials are in progress/planned in Australia and China, both as monotherapy and with combinations (e.g., rapamycin, everolimus)[1][2][3][8].
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